Xanthohumol

Xanthohumol is a highly active flavonoid naturally occurring in blossoming hops.

It has over 4 times higher antioxidant potential than vitamin C and is 200 times stronger than resveratrol.

The benefits of using Xanthohumol have been described in the scientific literature for years, but only now have we been able to use the properties of Xanthohumol in cosmetic formulations.

In cooperation with Polish scientists, we have developed an innovative and environmentally friendly method of synthesis of Xanthohumol. We increased its stability by closure in the cyclodextrin, creating a complex with high bio-availability and increased permeability through the epidermal layers. 

 

Discover the extraordinary potential of this inconspicuous molecule: 

ANTIOXIDANT ACTIVITY

Xanthohumol is one of the most potent antioxidants known to date, which effectively protects the skin from oxidative stress. Persistent inflammation caused by oxidative damage is the cause of accelerated skin aging (inflammaging) and numerous medical conditions, including: atopic dermatitis, psoriasis, acne, seborrheic dermatitis.

Xanthohumol as the strongest antioxidant, prevents alterations of proteins, such as oxidation and amino acid modification, which can lead to weakening of collagen fibers that build the skin. It also eliminates the peroxidation of lipids responsible for the construction of the lipid coat, reduces their permeability, increases stability and prevents disorders of transmembrane transport.

ANTI-INFLAMMATORY EFFECT

Xanthohumol has anti-inflammatory and anti-angiogenic properties. 

The basis of this effect are molecular mechanisms mainly involving the inhibition of cyclooxygenase (COX) and lipoxygenase (LOX) activity. 

Xanthohumol also reduces the production of inflammatory mediators (including TNF-α) by inhibiting the activity of transcription factors: NF-κB upon activation of lipopolysaccharide and STAT-1α and IRF-1 upon activation of IFN-γ.

ANTI-BACTERIAL ACTIVITY

Xanthohumol inhibits the growth of Gram-positive Staphylococcus aureus, Staphylococcus pyogenes and Staphylococcus epidermidis which cause purulent skin infection. It also has a strong bactericidal action against two other Gram-positive skin pathogens: Propionibacterium acnes and Kocura rhizophila.
The high activity inhibiting the growth of bacteria contributes to the effective care of problematic skin with acne vulgaris and rosacea liasons.

:

ANTIOXIDANT ACTIVITY

0%

Xanthohumol is one of the most potent antioxidants known to date, which effectively protects the skin from oxidative stress. Persistent inflammation caused by oxidative damage is the cause of accelerated skin aging (inflammaging) and numerous medical conditions, including: atopic dermatitis, psoriasis, acne, seborrheic dermatitis.

Xanthohumol as the strongest antioxidant, prevents alterations of proteins, such as oxidation and amino acid modification, which can lead to weakening of collagen fibers that build the skin. It also eliminates the peroxidation of lipids responsible for the construction of the lipid coat, reduces their permeability, increases stability and prevents disorders of transmembrane transport.

 

In terms of the most important parameters determining the antioxidant potential, xanthohumol exhibits values even higher than vitamin E or polyphenol 60.

CAPACITY OF NEUTRALIZING REACTIVE OXYGEN FORMS (ORAC) BY COMPOUNDS FOUND IN HOPS.

component
ORAC-H
ORAC-L
ORAC-Total
(Trolox equivalent)
(Trolox equivalent)
(Trolox equivalent)
Tetrahydroisohumulones (4)
0,034
0,011
0,045
Xanthohumol (7)
2,1
2,1
4,2
Vitamin C
1,4
1,4
Vitamin E
0,75
0,75
Polyphenon 60
4,2
0,006
4,2

ABILITY TO INTERCEPT SINGLET OXYGEN (SOAC) BY THE COMPOUNDS FOUND IN HOPS 

component
SOAC
(Vitamin E equivalent)
Humulones (1)
0,75
Lupulones (2)
0,80
Isohumulones (3)
0,40
Reduced isohumulones (5)
0,55
Tetrahydro-isohumulones (4)
0,59
Xanthohumol (7)
14,1
Vitamin E
1,00
Polyphenon 60
1,80

:

ANTI-INFLAMMATORY EFFECT

0%

Xanthohumol has anti-inflammatory and anti-angiogenic properties. 

The basis of this effect are molecular mechanisms mainly involving the inhibition of cyclooxygenase (COX) and lipoxygenase (LOX) activity. 

Xanthohumol also reduces the production of inflammatory mediators (including TNF-α) by inhibiting the activity of transcription factors: NF-κB upon activation of lipopolysaccharide and STAT-1α and IRF-1 upon activation of IFN-γ.

:

ANTI-BACTERIAL ACTIVITY

0%

Xanthohumol inhibits the growth of Gram-positive Staphylococcus aureus, Staphylococcus pyogenes and Staphylococcus epidermidis which cause purulent skin infection. It also has a strong bactericidal action against two other Gram-positive skin pathogens: Propionibacterium acnes and Kocura rhizophila.
The high activity inhibiting the growth of bacteria contributes to the effective care of problematic skin with acne vulgaris and rosacea liasons.

:

ANTI-AGING EFFECT

0%

Metalloproteinases are involved in aging processes in the skin, including increased distribution of extracellular matrix components, in particular collagen, elastin and fibronectin. Xanthohumol has a high inhibitory activity of the MMP-1 and MMP-8 metalloproteinases, hence slowing down the aging process.
At the same time, it protects the skin against photo-aging by reducing the negative effects of UV radiation.

:

BRIGHTENING EFFECT

0%

Keratinocytes, in response to oxidative stress induced by UVA and UVB radiation, produce GM-CSF cytokines that bind to a specific GMCSFR receptor and then activate STAT_1, STAT-3 and STAT-5 transduction signals. It is followed by stimulation of melanocytes and tyrosinase active proteins TRP1 and TRP2, leading to the formation of spots in the skin. 

Xanthohumol, by inhibiting the secretion of GM-CSF, contributes to lightening existing discolorations, inhibiting the formation of new ones and reducing redness of the skin.

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IMPROVEMENT OF SKIN MICROCIRCULATION

0%

Xanthohumol stimulates the micro-circulation of the skin, which promotes the removal of toxins and better nutrition and regeneration of tissues. There is visible improvement in the skin’s appearance due to better blood circulation.